WASHINGTON, Oct. 8, 2024 — LUNGevity Foundation, the nation’s leading lung cancer-focused nonprofit organization, announced the recipients of their 2024 Career Development Awards (CDAs) today.Â
Now in its 13th consecutive year, LUNGevity’s Career Development Awards program continues to champion the bold vision of the future where no one dies of lung cancer by supporting the brightest minds of today. These awards infuse the lung cancer research pipeline with innovative, early-career scientists working toward impactful solutions to improve our ability to diagnose and treat patients with lung cancer.
Awardees receive substantial funding for their research projects and exclusive mentorship opportunities with world-class experts. They also receive training in effective science communications.
“LUNGevity’s strategic focus on translational research helps the lung cancer community push the boundaries of discovery. These awards, and those from previous years, build on the creativity of scientists, helping turn their novel ideas into lifesaving solutions in the real world,” says Upal Basu Roy, PhD, MPH, executive director of LUNGevity Research. “We are excited to see how these inventive approaches and pioneering technologies will improve care for patients living with lung cancer.”
These are the recipients of this year’s award.
Julie Deutsch, MD
Johns Hopkins University School of Medicine
Next-Generation Pathologic Response Assessment in Patients with Lung Cancer
Non-small cell lung cancer (NSCLC) has seen an unprecedented burst of immunotherapies in the past decade – but none of these new therapies is effective for all patients. It is important to develop tests to determine which immunotherapy is most likely to benefit an individual patient. Dr. Deutsch and her team aim to engineer novel techniques by leveraging digitized biopsy samples and biospecimen analysis software (that originated in the space industry) to create tissue sample tests that can help oncologists identify optimal treatment plans for individual patients.
Tamar Nobel, MD, MPH
Montefiore Medical Center
Building Reliable Oncology Navigation to Ensure Adjuvant Management: BRONx-TEAM Project
Patients with early-stage NSCLC often benefit from therapy after surgery. However, non-White patients with lower socioeconomic status often do not receive these treatments. To help address this healthcare inequity, Dr. Nobel and her team are leveraging their experience developing patient navigation programs in the Bronx to improve postsurgical treatment plans for patients with NSCLC in Black and Hispanic communities with low socioeconomic status. Building on their strong position within the community, Dr. Nobel’s team will also gather genomic data to bolster our understanding of the unique needs of these underserved populations.
Yan Yang, PhD
University of Texas MD Anderson Cancer Center
Developing EGFRxHER3 Bispecific CAR-T cells for Targeting EGFR TKI DTPCs
Patients with advanced EGFR-positive NSCLC often benefit from being treated with tyrosine kinase inhibitors (TKIs) resulting in the bulk of tumor cells being killed. However, a few cancer cells (called drug-tolerant persister cells, or DTPCs) manage to survive treatment. Researchers believe DTPCs may be responsible for the tumor developing drug resistance and growing back unchecked. CAR-T cell therapy is a new form of cancer treatment that involves engineering T cells to kill cancer cells. Dr. Yang’s team conducted preliminary studies that suggest targeting HER3 and EGFR simultaneously with CAR-T cells could be an effective way to eradicate DTPCs. In this project, they will conduct the key laboratory tests needed to confirm their hypothesis. If these studies are successful, they will work to test this potential treatment in a clinical trial.
LUNGevity would like to thank Boehringer Ingelheim, Genentech, and Merck for their generous support of these research awards.
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