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Removing a Molecular Brake – Regnase-1 Deletion Boosts CAR T-Cell Activity Against Pediatric Osteosarcoma

Investigators at St. Jude Children’s Research Hospital have shown in preclinical models that deleting a single inhibitory gene from CAR T-cells improves their ability...

CD79b-Targeted ADC Produces Durable Remission After CAR T-Cell Failure in Mantle Cell Lymphoma

A case report describes a prolonged remission in a patient with mantle cell lymphoma (MCL) who relapsed after CD19-directed chimeric antigen receptor (CAR) T-cell...

BCMA-directed CAR T-cell Therapy Demonstrates Profound Efficacy in High-risk Smoldering Multiple Myeloma: Results from the CAR-PRISM Phase 2 Trial

High-risk smoldering multiple myeloma (HR-SMM) is a precursor to symptomatic multiple myeloma, characterized by a significantly increased risk of progression to active disease with...

AACR 2026: Next-Generation Cell Therapy Show Promise in Solid and Hematologic Malignancies

Chimeric antigen receptor (CAR) T-cell therapies have revolutionized the treatment of hematologic malignancies but have faced significant challenges in solid tumors and long-term persistence...

Jiahui International Cancer Center Successfully Treats a 78-year-old Patient from New Zealand with Advanced CAR T-Cell Therapy

In early November, a team of physicians at Jiahui International Cancer Center (JICC), part of Jiahui International Hospital, Shanghai’s first large-scale international tertiary hospital,...

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Investigators at St. Jude Children’s Research Hospital have shown in preclinical models that deleting a single inhibitory gene from CAR T-cells improves their ability...

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