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CD79b-Targeted ADC Produces Durable Remission After CAR T-Cell Failure in Mantle Cell Lymphoma

A case report describes a prolonged remission in a patient with mantle cell lymphoma (MCL) who relapsed after CD19-directed chimeric antigen receptor (CAR) T-cell...

BCMA-directed CAR T-cell Therapy Demonstrates Profound Efficacy in High-risk Smoldering Multiple Myeloma: Results from the CAR-PRISM Phase 2 Trial

High-risk smoldering multiple myeloma (HR-SMM) is a precursor to symptomatic multiple myeloma, characterized by a significantly increased risk of progression to active disease with...

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CD79b-Targeted ADC Produces Durable Remission After CAR T-Cell Failure in Mantle Cell Lymphoma

A case report describes a prolonged remission in a patient with mantle cell lymphoma (MCL) who relapsed after CD19-directed chimeric antigen receptor (CAR) T-cell...

BCMA-directed CAR T-cell Therapy Demonstrates Profound Efficacy in High-risk Smoldering Multiple Myeloma: Results from the CAR-PRISM Phase 2 Trial

High-risk smoldering multiple myeloma (HR-SMM) is a precursor to symptomatic multiple myeloma, characterized by a significantly increased risk of progression to active disease with...

AACR 2026: Next-Generation Cell Therapy Show Promise in Solid and Hematologic Malignancies

Chimeric antigen receptor (CAR) T-cell therapies have revolutionized the treatment of hematologic malignancies but have faced significant challenges in solid tumors and long-term persistence...

Jiahui International Cancer Center Successfully Treats a 78-year-old Patient from New Zealand with Advanced CAR T-Cell Therapy

In early November, a team of physicians at Jiahui International Cancer Center (JICC), part of Jiahui International Hospital, Shanghai’s first large-scale international tertiary hospital,...

Carl June, Bruce Levine, Isabelle Rivière, and Michel Sadelain Receive the 2025 Merkin Prize

The 2025 Richard N. Merkin Prize in Biomedical Technology was jointly awarded to Carl June, Bruce Levine, Isabelle Rivière, and Michel Sadelain in a ceremony...

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A case report describes a prolonged remission in a patient with mantle cell lymphoma (MCL) who relapsed after CD19-directed chimeric antigen receptor (CAR) T-cell...

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